Emergency services were called to a burning house at Wilshire Court in Endeavor Hills at around 6.30pm yesterday.
Firefighters arrived on the scene within six minutes and discovered the entire house was already engulfed in fire, according to Fire Rescue Victoria.
They searched the house and evacuated a 70-year-old woman who was found inside.
She was taken to Dandenong Hospital for observation.
A man was found dead inside the house.
Firefighters brought the fire under control in 29 minutes.
The police are investigating the incident.